I just upgraded to iTunes 10 and ScrobblePod, thankfully, didn't break. I'm not scrobbling iPod/iPhone/iPad playback or doing anything with podcasts, so I can't vouch for compatibility with that stuff... but for regular music scrobbling I'm happy that it continues to work. Mac OS X 10.6.4 on a 2007 MacBook. This should hopefully be good news for ScrobblePod users unsure about upgrading. Post your own experiences here in this thread.
Still works with iTunes 10